Alisol F 24-acetate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Alisol F 24-acetate 是从泽泻 (Alisma plantago-aquatica Linn) 中分离出来的天然产物。 Alisol F 24 Acetate 通过抑制 P-糖蛋白介导的药物流出来增强 MCF-7/DOX 细胞的化疗敏感性和细胞凋亡。

Alisol F 24-acetate is a natural product isolated from Alisma plantago-aquatica Linn. Alisol F 24 Acetate enhances chemosensitivity and apoptosis of MCF-7/DOX Cells by inhibiting P-Glycoprotein-Mediated drug efflux.

:Cell Viability Assay Cell Line:Caco-2 cells and MCF-7/DOX cells.Concentration:1, 2, 5, 10, 20, 50 and 100 μM.Incubation Time:24 h.Result:Significantly inhibited the cell viability (100 μM).Apoptosis Analysis Cell Line:MCF-7/DOX cells.Concentration:5, 10 and 20 μM.Incubation Time:0.5, 1, 2, 3 and 4 h.Result:Promoted the doxorubicin-induced apoptosis with time and dose dependent manner.

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Membrane Transporter/Ion Channel

P-glycoprotein

P-gp

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443683-76-9

530.746

C32H50O6

>98% (HPLC)

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[H][C@@]12[C@@H](O)CC3=C4C(C[C@]3(C)[C@@]1(C)CCC1C(C)(C)C(=O)CC[C@]21C)O[C@@H](C[C@H]4C)[C@@H](OC(C)=O)C(C)(C)O

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(-20℃)

With Ice Pack

≥ 2 years